Dedicated to Mary Most Holy of the Annunciation, the church was built in Gothic style on a Latin cross plan in the 12th century upon a pre-existing Roman temple.
Over the centuries, the façade underwent numerous restorations and refurbishments initially as a result of a fire in 1190, then a powerful earthquake in 1246 and finally the caving in of a part of the roof in 1322, disfiguring some of its more unique features.
A magnificent rose window opens up from overhead that was begun in 1515 under Bishop Basilio Moscardi and completed under his successor Aldighieri Biliotti (1517-1523). A band of acanthus ornament arches over the front entrance with an image of Christ Blessing in the centre. The inside of the Cathedral is subdivided into three large naves, with a small, elegant fourth nave to the extreme right housing a baptismal font added in 1358. On the counter-façade, there is a large, striking fresco painted by Ferraù of Faenza (called “Il Faenzone”) depicting a Micheangelo-esque Universal Judgement.
There is a giant fresco depicting the Universal Judgment by Ferraù Faenzone. The choir includes the Gothic altar and a wooden choir-enclosure with two floors.