The small town of Lisciano Niccone, which is to be found in the valley of the "Niccone" stream, nowadays has less than a thousand inhabitants, whose main activity is agriculture.

After having been part of the dominion of Perugia during the Middle Ages, the town passed under the rule of the Papal State in the 16th century and followed that State's slow decay. Nowadays, it still preserves the ruins of the 11th century Castle which testifies to its ancient origins and to the importance which it has now lost, and which formerly was due to its important strategic position in the upper Tiber valley.